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Microvascular Coronary Disease
Cox proportional hazards models were used to examine the association between covariates and events, sequentially adding demographic and clinical factors, followed by body mass index BMI and then coronary flow reserve CFR. This study reports an inverted J—shaped relationship between BMI and CFR in patients referred for cardiac stress testing, with higher BMI in obese patients associated with worsening coronary microvascular function, independently of clinical risk factors.
Furthermore, in obese patients, only those with impaired CFR demonstrated a significantly increased risk of events. Additional prospective studies are needed to determine whether CMD may identify obese individuals most likely to benefit from bariatric surgery or other weight loss interventions.
- Microvascular Coronary Disease (MCD) | Cleveland Clinic.
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- Table 1: Diagnostic Tests for Coronary Microvascular Dysfunction;
Study Questions: What is the relationship among obesity, coronary microvascular dysfunction CMD , and adverse outcomes?
Related Coronary Microvascular Dysfunction
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